细胞周期蛋白、细胞周期蛋白依赖性激酶与癌症。
Cyclins, CDKs and cancer.
作者信息
Pines J
机构信息
Wellcome/CRC Institute, Cambridge, UK.
出版信息
Semin Cancer Biol. 1995 Apr;6(2):63-72. doi: 10.1006/scbi.1995.0009.
PMID:7647308
Abstract
The connections between cancer and the basic machinery of the cell cycle have taken a surprisingly long time to become apparent. However, the past 2 years has seen a dramatic increase in the number of cell cycles regulators that have been implicated as either protooncogenes or as tumour suppressor genes. In this review I will attempt to show how perturbations in the known cell cycle regulators may play a part in the process of oncogenesis.
摘要
癌症与细胞周期基本机制之间的联系花了惊人长的时间才变得明显。然而，在过去两年中，被认为是原癌基因或肿瘤抑制基因的细胞周期调节因子的数量急剧增加。在这篇综述中，我将试图展示已知的细胞周期调节因子的扰动如何可能在肿瘤发生过程中起作用。
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