Whyte P
Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ont., Canada.
Semin Cancer Biol. 1995 Apr;6(2):83-90. doi: 10.1006/scbi.1995.0011.
The retinoblastoma tumor suppressor gene is inactivated in retinoblastomas and a variety of other tumor types. In addition, it is one of several cellular proteins targeted by the transforming proteins of the small DNA tumor viruses. At least two other cellular proteins that are targeted by the viral transforming proteins are structurally and functionally related to the protein encoded by the retinoblastoma tumor suppressor gene. Recent data has described a complex series of interactions with cyclins, kinases and transcription factors. It is presumably through these interactions that the retinoblastoma-related proteins exert their effects on cellular proliferation.
视网膜母细胞瘤抑癌基因在视网膜母细胞瘤和多种其他肿瘤类型中失活。此外，它是小型DNA肿瘤病毒的转化蛋白所靶向的几种细胞蛋白之一。病毒转化蛋白所靶向的至少另外两种细胞蛋白在结构和功能上与视网膜母细胞瘤抑癌基因编码的蛋白相关。最近的数据描述了与细胞周期蛋白、激酶和转录因子的一系列复杂相互作用。视网膜母细胞瘤相关蛋白可能正是通过这些相互作用对细胞增殖产生影响。
