Classon Marie, Harlow Ed
MGH Cancer Center, Building 149, 13th Street, Room 7330, Charlestown, Massachusetts 02129, USA.
Nat Rev Cancer. 2002 Dec;2(12):910-7. doi: 10.1038/nrc950.
Since its discovery, the retinoblastoma (RB) tumour-suppressor protein has been a focal point of cancer research. Accumulating evidence indicates a complex role for RB in cell proliferation, differentiation and survival. To further complicate matters, proteins that are related to RB have redundant as well as antagonistic functions. Recent studies of knockout mice and cells that lack one or more of these proteins have begun to clarify their various context-specific functions and the unique activity of this tumour suppressor.
自视网膜母细胞瘤（RB）肿瘤抑制蛋白被发现以来，它一直是癌症研究的焦点。越来越多的证据表明，RB在细胞增殖、分化和存活中发挥着复杂的作用。更复杂的是，与RB相关的蛋白质具有冗余和拮抗功能。最近对缺乏一种或多种这些蛋白质的基因敲除小鼠和细胞的研究，已开始阐明它们在不同背景下的各种功能以及这种肿瘤抑制因子的独特活性。
