Takahashi H, Iwabuchi K, Kudo Y, Tomoike H, Niizeki K, Uchida K, Takahashi K
First Department of Internal Medicine, Yamagata University School of Medicine.
Intern Med. 1995 May;34(5):330-8. doi: 10.2169/internalmedicine.34.330.
Pulmonary diffusing capacity for CO (DLCO) and cardiac output (Q) were simultaneously measured by a noninvasive rebreathing method (RB) in 15 normal subjects and in 60 patients, including cardiac diseases (CD), bronchial asthma (BA), chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (PF). DLCO and Q were tested by the single breath method (SB) and the dye-dilution method (Dye), respectively. DLCO (RB) correlated well with DLCO (SB) (r = 0.890, p < 0.001). Q(RB) also correlated well with Q(Dye) (r = 0.909, p < 0.001). Factors affecting DLCO (RB) were age, height, body surface area, O2 consumption, Q, hematocrit (Het) and Q.Hct, among which Q.Hct was the prominent influential determinant. DLCO per lung volume was smaller in COPD and PF than in BA or healthy subjects, while, the ratio of DLCO/(Q.Hct) was significantly higher in COPD than in PF. Simultaneous measurements of DLCO and Q offer comprehensive characterization for functional changes in lung parenchyma.
采用无创再呼吸法（RB）对15名正常受试者和60名患者（包括患有心脏病（CD）、支气管哮喘（BA）、慢性阻塞性肺疾病（COPD）和特发性肺纤维化（PF）的患者）同时测量了一氧化碳肺弥散量（DLCO）和心输出量（Q）。分别采用单次呼吸法（SB）和染料稀释法（Dye）对DLCO和Q进行检测。DLCO（RB）与DLCO（SB）相关性良好（r = 0.890，p < 0.001）。Q（RB）与Q（Dye）也相关性良好（r = 0.909，p < 0.001）。影响DLCO（RB）的因素有年龄、身高、体表面积、耗氧量、Q、血细胞比容（Het）和Q·Het，其中Q·Het是主要的影响决定因素。COPD和PF患者每肺容积的DLCO低于BA患者或健康受试者，而COPD患者的DLCO/（Q·Het）比值显著高于PF患者。同时测量DLCO和Q可全面表征肺实质的功能变化。
