Zhang H, Liang M J, Ma Z X
Guangzhou Hospital of TCM.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995 Apr;15(4):213-5.
102 cases of coronary heart disease (CHD) were divided randomly into two groups, 70 cases were given orally the Buyang Huanwu Decoction (BYHWD) for 15 days and were compared with 32 control patients. The effect of BYHWD in treating angina pectoris and the change of EKG before and after the treatment were observed. The results were as follows: in BYHWD group the serum level of lipoperoxide (LPO), apolipoprotein (apo) B100, LPO/SOD (superoxide dismutase) and apo B100/apo A1 were lowered remarkably, the serum of SOD and apo A1 were elevated significantly (P < 0.01) comparing with the control group. The total effective rate of treating angina pectoris was 91.4%. But the difference was insignificant compared with the control group (P < 0.05). The EKG improvement rate was 85.7% in BYHWD group, the difference was very significant comparing with control group (P < 0.05). The results indicated that BYHWD had a good effect on removing the oxygen free radicals, reducing the injury of LPO and regulating the apolipoprotein metabolism in the patients with CHD. Therefore BYHWD is an effective TCM remedy for CHD.
102例冠心病患者随机分为两组，70例口服补阳还五汤15天，并与32例对照患者进行比较。观察补阳还五汤治疗心绞痛的疗效及治疗前后心电图的变化。结果如下：补阳还五汤组血清过氧化脂质（LPO）、载脂蛋白（apo）B100、LPO/超氧化物歧化酶（SOD）及apo B100/apo A1水平明显降低，血清SOD及apo A1水平明显升高（P<0.01），与对照组比较差异有统计学意义。治疗心绞痛的总有效率为91.4%，但与对照组比较差异无统计学意义（P<0.05）。补阳还五汤组心电图改善率为85.7%，与对照组比较差异有统计学意义（P<0.05）。结果表明，补阳还五汤对冠心病患者清除氧自由基、减轻LPO损伤及调节载脂蛋白代谢有良好作用。因此，补阳还五汤是治疗冠心病的有效中药方剂。
