Fal A M, Małolepszy J, Dobek R
Katedry i Kliniki Chorób Wewnetrznych i Alergologii Akademii Medycznej we Wrocławiu.
Pneumonol Alergol Pol. 1995;63(3-4):167-9.
The study was set up in order to check the usefulness of peripheral blood eosinophilia in asthma diagnosis and asthma therapy monitoring. Twenty mild asthmatics entered the study--ten atopic and ten nonatopic. Eosinophilia was estimated twice: on the day of admission and twenty four hours after bronchial provocation. Bronchial hyperreactivity was measured on both occasions. We showed, that there was no difference in eosinophilia between atopic and nonatopic subjects before provocation but the difference was significant 24 hrs after provocation. In both groups of asthmatics eosinophilia correlated with bronchial hyperreactivity before and after provocation. We concluded, that eosinophilia is an easy and valuable parameter in monitoring the degree of allergic inflammation in asthmatics.
开展这项研究是为了检验外周血嗜酸性粒细胞增多在哮喘诊断及哮喘治疗监测中的作用。20名轻度哮喘患者参与了研究，其中10名是特应性患者，10名是非特应性患者。嗜酸性粒细胞增多情况进行了两次评估：入院当天以及支气管激发试验24小时后。两次均测量了支气管高反应性。我们发现，激发试验前特应性和非特应性受试者的嗜酸性粒细胞增多情况无差异，但激发试验24小时后差异显著。在两组哮喘患者中，激发试验前后嗜酸性粒细胞增多情况均与支气管高反应性相关。我们得出结论，嗜酸性粒细胞增多是监测哮喘患者过敏性炎症程度的一个简单且有价值的指标。
