Małolepszy J, Fal A M
Katedry i Kliniki Chorób Wewnetrznych i Alergologii, Akademii Medycznej we Wrocławiu.
Pneumonol Alergol Pol. 1995;63(9-10):484-9.
The study was set up to evaluate the changes in broncho-alveolar lavage cell-count in asthmatics after bronchial provocation. Similarities and differences between atopic (A) and nonatopic (N) asthma were given a special concern. Twenty mild asthmatics--10 A and 10 N. There was no difference in BAL eosinophila between these groups before provocation. After provocation more eosinophils were found in A group (p = 0.06). Neutrophils were more numerous in N on both occasions--0 = 0.00003 and p = 0.006 respectively). Lymphocytes showed a similar pattern--p = 0.03, p = 0.003. A positive correlation between BAL eosinophilia and bronchial hyperreactivity was shown in both groups. Inflammation, including inflammatory cells plays a major role in bronchial asthma pathophysiology. It seems to be more expressed in nonatopic patients.
本研究旨在评估哮喘患者支气管激发试验后支气管肺泡灌洗细胞计数的变化。特别关注了特应性（A）哮喘和非特应性（N）哮喘之间的异同。20名轻度哮喘患者，其中10名特应性哮喘患者和10名非特应性哮喘患者。激发试验前，两组支气管肺泡灌洗嗜酸性粒细胞无差异。激发试验后，A组发现更多嗜酸性粒细胞（p = 0.06）。两次检查时，N组中性粒细胞均较多，分别为p = 0.00003和p = 0.006。淋巴细胞呈现类似模式，分别为p = 0.03和p = 0.003。两组均显示支气管肺泡灌洗嗜酸性粒细胞增多与支气管高反应性呈正相关。炎症，包括炎症细胞在支气管哮喘病理生理学中起主要作用。在非特应性患者中似乎表现得更为明显。
