de Groot C M, Bornstein R A, Spetie L, Burriss B
Department of Psychiatry, Ohio State University, Columbus 43210, USA.
Ann Clin Psychiatry. 1994 Dec;6(4):227-33. doi: 10.3109/10401239409149009.
The current study was undertaken to explore the course of tics in Gilles de la Tourette's syndrome (TS). As part of a prospective 5-year follow-up of non-clinically based TS subjects who had originally participated in a comprehensive research protocol, 23 subjects (ages 11 to 53 years) were reevaluated for tics and obsessive-compulsive (OC) characteristics. Three (13%) of the subjects had an improvement in total tic symptomatology, while 15 (65.2%) had no change and 5 (21.7%) worsened. Improvement or worsening was independent of baseline developmental age across child, adolescent, and adult subgroups. Complex motor tics at baseline predicted complex motor tics and simple phonic tics at follow-up. Baseline OC and complex motor tics independently predicted subsequent OC and complex motor symptoms. Data from the current study provide evidence of the stability of tic subtypes over time and developmental period.
本研究旨在探讨抽动秽语综合征（TS）中抽动症状的发展过程。作为对最初参与一项全面研究方案的非临床TS受试者进行的为期5年的前瞻性随访的一部分，对23名受试者（年龄11至53岁）的抽动症状和强迫（OC）特征进行了重新评估。3名受试者（13%）的抽动症状总体有所改善，15名（65.2%）无变化，5名（21.7%）病情恶化。改善或恶化情况与儿童、青少年和成人亚组的基线发育年龄无关。基线时的复杂运动抽动可预测随访时的复杂运动抽动和简单发声抽动。基线时的OC和复杂运动抽动可独立预测随后的OC和复杂运动症状。本研究的数据提供了抽动亚型随时间和发育阶段稳定性的证据。
