Apter J T, Kushner S F, Woolfolk R L
Department of Psychology, Rutgers University, New Brunswick, New Jersey, USA.
Ann Clin Psychiatry. 1994 Dec;6(4):255-8. doi: 10.3109/10401239409149012.
Many patients fail to respond to one or more trials with a single antidepressant. In such cases polypharmacy is often necessary and beneficial, although there may be an increased risk of complications. Four case reports are presented of patients with refractory depression treated successfully with the combination of the tricyclic antidepressant nortriptyline and the newer agent bupropion.
许多患者对单一抗抑郁药进行的一项或多项试验均无反应。在这种情况下，联合用药往往是必要且有益的，尽管并发症风险可能会增加。本文报告了4例难治性抑郁症患者，他们通过三环类抗抑郁药去甲替林与新型药物安非他酮联合使用而成功治愈。
