Hashimoto O, Harada M, Sata M, Imamura K, Matsukuma N, Fukushima H, Itano S, Ohishi M, Ueno T, Iemura A
Social Insurance Kurume Daiichi Hospital, Japan.
J Gastroenterol. 1995 Jun;30(3):403-7. doi: 10.1007/BF02347519.
A 47-year-old man with primary amyloidosis was admitted with abdominal pain. A new radionuclide liver imaging technique using Technetium-99m diethylenetriamine-pentaacetic acid-galactosyl human serum albumin, was performed and the serum hyaluronate concentration was measured. Although ordinary laboratory tests revealed only slight abnormalities, the uptake of the radiolabelled ligand for hepatocyte asialo-glycoprotein receptors was decreased, and marked hepatomegaly was revealed. Furthermore, the serum hyaluronate level was elevated. Histological examination of a hepatic needle biopsy specimen revealed a marked deposition of amyloid in the hepatic perisinusoidal spaces. These results indicate that this new radionuclide liver imaging technique (using Technetium-99m diethylenetriamine-pentaacetic acid-galactosyl human serum albumin) and the measurement of serum hyaluronate may be useful supplementary tools for identifying amyloid deposition in the hepatic perisinusoidal spaces in patients with amyloidosis.
一名47岁的原发性淀粉样变性男性因腹痛入院。采用锝-99m二乙三胺五乙酸-半乳糖基人血清白蛋白进行了一项新的放射性核素肝脏成像技术检查，并测定了血清透明质酸盐浓度。尽管常规实验室检查仅显示轻微异常，但肝细胞去唾液酸糖蛋白受体放射性标记配体的摄取减少，且显示有明显肝肿大。此外，血清透明质酸盐水平升高。肝脏穿刺活检标本的组织学检查显示肝血窦周围间隙有明显的淀粉样蛋白沉积。这些结果表明，这种新的放射性核素肝脏成像技术（使用锝-99m二乙三胺五乙酸-半乳糖基人血清白蛋白）和血清透明质酸盐的测定可能是用于识别淀粉样变性患者肝血窦周围间隙淀粉样蛋白沉积的有用辅助手段。
