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病毒结构与构象重排

Virus structures and conformational rearrangements.

作者信息

Harrison S C

机构信息

Howard Hughes Medical Institute, Harvard University, Cambridge, USA.

出版信息

Curr Opin Struct Biol. 1995 Apr;5(2):157-64. doi: 10.1016/0959-440x(95)80070-0.

Abstract

Structural virology is a burgeoning subspecialty. Our understanding of the molecular organization of viruses has begun to contribute directly to the analysis of viral attachment and entry, assembly, antigenicity, and even viral pathogenesis, but there are still more puzzles than answers. Recent crystallographic results have helped us to understand the structural changes in viruses that affect their assembly and infectivity.

摘要

结构病毒学是一个新兴的亚专业领域。我们对病毒分子结构的理解已开始直接有助于分析病毒的附着与进入、组装、抗原性乃至病毒致病机制,但谜题仍多于答案。近期的晶体学研究结果有助于我们了解病毒中影响其组装和感染性的结构变化。

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