Huang X J, Guo N L, Zheng R
Institute of Hematology, BMU Beijing.
Zhonghua Liu Xing Bing Xue Za Zhi. 1995 Apr;16(3):166-70.
Hepatitis virus infection is a special problem in China and the role of Hepatitis virus infection in allogeneic bone marrow transplantation (BMT) is not well-defined. In this study, 106 BMT patients were included for analysis of the role of virus infection in allo-BMT. Seven and 65 of 106 patients were found to have HBV infection and HCV infection, respectively. Neither HBV infection and HCV infection interfered with the engraftment of bone marrow cells nor increased the rate of AGVHD, CGVHD, VOID. Neither HBV infection nor HCV infection prohibited allo-BMT. But Hepatitis virus infection can cause mild to moderate liver dysfunction, even death because of acute liver function failure, active prevention and treatment of hepatitis virus infection remains necessary. In this respect, rh-interferon is useful.
肝炎病毒感染在中国是一个特殊问题，且肝炎病毒感染在异基因骨髓移植（BMT）中的作用尚不明确。在本研究中，纳入了106例BMT患者以分析病毒感染在异基因BMT中的作用。106例患者中分别有7例和65例被发现感染了HBV和HCV。HBV感染和HCV感染均未干扰骨髓细胞的植入，也未增加急性移植物抗宿主病（AGVHD）、慢性移植物抗宿主病（CGVHD）、静脉闭塞病（VOID）的发生率。HBV感染和HCV感染均未禁止进行异基因BMT。但是肝炎病毒感染可导致轻至中度肝功能障碍，甚至因急性肝功能衰竭而死亡，因此积极预防和治疗肝炎病毒感染仍然必要。在这方面，重组人干扰素是有用的。
