Wang S J, Kao C H, Lin W Y, Hsu C Y, Chang C P, Lan J L
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taipei, Taiwan.
Clin Nucl Med. 1995 Jun;20(6):494-6. doi: 10.1097/00003072-199506000-00004.
This study evaluated the effect of inhalation of steroids on lung permeability in patients with asthma by measuring the clearance of Tc-99m DTPA aerosol from the alveolar to vascular space. Twenty patients with asthma were studied in the supine position with a gamma camera and the clearance half time (T 1/2) was calculated. The base line lung permeability study was performed before treatment with inhalation of 100 micrograms beclomethasone dipropionate four times daily for 1 week, then the study was repeated. After treatment with inhalation of steroid, there was a change in T 1/2 from 76.4 +/- 37.4 minutes to 86.6 +/- 48.2 minutes (P = 0.08). This preliminary study suggests that lung permeability is not altered by inhaled steroid therapy.
本研究通过测量锝-99m二乙三胺五醋酸（Tc-99m DTPA）气溶胶从肺泡到血管腔的清除率，评估吸入类固醇对哮喘患者肺通透性的影响。对20例哮喘患者采用γ相机进行仰卧位研究，并计算清除半衰期（T1/2）。在每日4次吸入100微克丙酸倍氯米松治疗1周前进行基线肺通透性研究，然后重复该研究。吸入类固醇治疗后，T1/2从76.4±37.4分钟变为86.6±48.2分钟（P = 0.08）。这项初步研究表明，吸入类固醇治疗不会改变肺通透性。
