Chen A C, Tsai F J, Tsai C H, Lin C C, Lee C C, Kao C H
Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan.
Lung. 2003;181(5):283-9. doi: 10.1007/s00408-003-1032-z.
This study evaluated the effects of fluticasone propionate inhalation therapy on lung ventilation and alveolar permeability by quantitative Tc-99m DTPA radioaerosol inhalation lung scintigraphy in 15 children with asthma. Lung ventilation was evaluated as the distribution percentage (D%) of Tc-99m DTPA radioaerosols in the central, intermediate and peripheral regions of the right lung. Alveolar permeability was measured by the rate of Tc-99m DTPA radioaerosol clearance curve from the peripheral alveoli of the right lung and represented as slope. The D% and slopes were calculated before and after one-week inhalation therapy (100 microg fluticasone propionate two times daily for one-week) to evaluate the effects of inhalation therapy on lung ventilation and alveolar permeability. The preliminary results revealed statistically significantly improved lung ventilation but no significant change of alveolar permeability in the right lung after one-week fluticasone propionate inhalation therapy in children with asthma. We suggest that the widely available and noninvasive Tc-99m DTPA radioaerosol inhalation lung scintigraphy can simultaneously evaluate lung ventilation and alveolar permeability in one study and should contribute to any disorder involving both alveoli and airways.
本研究通过对15例哮喘患儿进行定量锝-99m二乙三胺五醋酸（Tc-99m DTPA）放射性气溶胶吸入肺闪烁显像，评估丙酸氟替卡松吸入疗法对肺通气和肺泡通透性的影响。肺通气以锝-99m DTPA放射性气溶胶在右肺中央、中间和周边区域的分布百分比（D%）来评估。肺泡通透性通过锝-99m DTPA放射性气溶胶从右肺周边肺泡清除曲线的速率来测量，并表示为斜率。在为期一周的吸入治疗（每日两次，每次100微克丙酸氟替卡松，共一周）前后计算D%和斜率，以评估吸入治疗对肺通气和肺泡通透性的影响。初步结果显示，哮喘患儿在接受一周的丙酸氟替卡松吸入治疗后，右肺的肺通气有统计学意义的显著改善，但肺泡通透性无显著变化。我们认为，广泛可用且无创的Tc-99m DTPA放射性气溶胶吸入肺闪烁显像可在一项研究中同时评估肺通气和肺泡通透性，应为涉及肺泡和气道的任何疾病提供帮助。
