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希腊北部老年人糖尿病流行病学:一项人群研究。

Epidemiology of diabetes mellitus in the elderly in northern Greece: a population study.

作者信息

Papazoglou N, Manes C, Chatzimitrofanous P, Papadeli E, Tzounas K, Scaragas G, Kontogiannis I, Alexiades D

机构信息

Department of Internal Medicine, St Paul General Hospital, Thessaloniki, Greece.

出版信息

Diabet Med. 1995 May;12(5):397-400. doi: 10.1111/j.1464-5491.1995.tb00502.x.

Abstract

This population based study was undertaken to ascertain the overall prevalence of diabetes mellitus (DM) and impaired glucose tolerance (IGT) in the elderly using the WHO criteria. The role of obesity in the development of DM or IGT has been investigated for both sexes per decade of age. Furthermore the potential for DM to increase with age, as has been suggested before, has been evaluated using the IGT as a proportion of total glucose intolerance (IGT/TGI) for the same parts of the tested sample. From the 647 persons registered as elderly people in a small town in northern Greece (total population 5875 people), 66 persons did not participate in this survey. Fifty-six subjects (9.7%) had previously diagnosed DM. The remainder were tested using fasting blood glucose measurements or an oral glucose tolerance test (OGTT). The prevalence of previously undiagnosed DM according to fasting blood glucose values or after 2 h of 75 g load values was 10.1% and 9.3%, respectively. Thus the overall prevalence of DM was 29.1% and of IGT was 15.1%. These data support an increased frequency of DM (65% previously undiagnosed) and IGT in the elderly, whereas this population's susceptibility seems to decline in the older groups for both sexes. Obesity remains a risk factor for DM and IGT particularly among the younger groups although its role has been found to decline with age.

摘要

这项基于人群的研究旨在根据世界卫生组织标准确定老年人中糖尿病(DM)和糖耐量受损(IGT)的总体患病率。已按每十岁年龄组对肥胖在DM或IGT发生中的作用进行了男女两性调查。此外,如之前所提示的,已通过将IGT作为测试样本相同部分中总糖耐量异常(IGT/TGI)的比例,对DM随年龄增长的可能性进行了评估。在希腊北部一个小镇登记的647名老年人(总人口5875人)中,66人未参与此项调查。56名受试者(9.7%)既往已诊断为DM。其余受试者采用空腹血糖测量或口服葡萄糖耐量试验(OGTT)进行检测。根据空腹血糖值或75g负荷后2小时的值,既往未诊断DM的患病率分别为10.1%和9.3%。因此,DM的总体患病率为29.1%,IGT为15.1%。这些数据支持老年人中DM(65%既往未诊断)和IGT的发生率增加,而该人群的易感性在两个性别的老年组中似乎下降。肥胖仍然是DM和IGT的一个危险因素,尤其是在较年轻组中,尽管其作用已被发现随年龄下降。

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