Lu S, Shi Y, Yi H
Obstetric and Gynecologic Hospital, Zhejiang Medical University, Hangzhou.
Zhonghua Fu Chan Ke Za Zhi. 1995 May;30(5):294-7.
The production of tumor necrosis factor (TNF) induced by lipopolysaccharide (LPS) in peripheral blood mononuclear cells (PBMC) from normal woman were determined. The study investigated the role of regulation of estradiol (E2) and progesterone (P) in the production of TNF in-vitro. The results showed that PBMC would produce TNF when stimulated by E2 or P in culture in-vitro. The appropriate dosages were 125 pmol/L in E2 and 10-20 nmol/L in P. The findings suggested that some sex hormones could play a regulating role in the production of TNF by PBMC. E2 and P may be endogenous substances capable of inducing TNF production. The results revealed a beneficial aspect of sex hormones in anti-cancer treatment.
测定了正常女性外周血单个核细胞（PBMC）中脂多糖（LPS）诱导的肿瘤坏死因子（TNF）的产生。该研究调查了雌二醇（E2）和孕酮（P）在体外调节TNF产生中的作用。结果表明，PBMC在体外培养中受到E2或P刺激时会产生TNF。合适的剂量为E2 125 pmol/L，P 10 - 20 nmol/L。研究结果表明，某些性激素可能在PBMC产生TNF的过程中发挥调节作用。E2和P可能是能够诱导TNF产生的内源性物质。该结果揭示了性激素在抗癌治疗中的有益作用。
