Pianosi P, Khoo M C
Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada.
Eur J Appl Physiol Occup Physiol. 1995;70(4):360-6. doi: 10.1007/BF00865034.
A single-breath CO2 test of peripheral chemosensitivity has recently been described, and elaborated based on model simulations. This study was designed to measure the peripheral CO2 chemoreflex at rest and during heavy exercise to see if carotid chemosensitivity to CO2 increased. Ten healthy, adult males performed an incremental exercise test to determine their ventilatory anaerobic threshold (VAT), and 20 minutes of steady-state exercise at a pre-determined power output above VAT. Arterialized venous blood was obtained during each minute of incremental exercise to verify development of metabolic acidosis. Carotid chemosensitivity was tested repeatedly at rest and in steady-state exercise by the ventilatory response to a single breath of 13% CO2 in air. The peripheral chemoreflex for CO2 for the group of subjects doubled from rest to exercise (mean 0.096 l.s-1.kPa-1) with all subjects showing an increase. We conclude that the gain of the carotid CO2 chemoreflex increases from rest to exercise at work above the VAT.
最近有人描述了一种用于测量外周化学敏感性的单次呼吸二氧化碳测试，并基于模型模拟进行了详细阐述。本研究旨在测量静息状态和剧烈运动期间的外周二氧化碳化学反射，以观察颈动脉对二氧化碳的化学敏感性是否增加。十名健康成年男性进行了递增运动测试，以确定其通气无氧阈（VAT），并在高于VAT的预定功率输出下进行20分钟的稳态运动。在递增运动的每分钟采集动脉化静脉血，以验证代谢性酸中毒的发生。通过对空气中单次呼吸13%二氧化碳的通气反应，在静息状态和稳态运动中反复测试颈动脉化学敏感性。该组受试者的外周二氧化碳化学反射从静息状态到运动状态增加了一倍（平均为0.096 l·s⁻¹·kPa⁻¹），所有受试者均表现出增加。我们得出结论，在高于VAT的工作强度下，从静息状态到运动状态，颈动脉二氧化碳化学反射的增益增加。
