Fomsgaard A, Høiby N, Friis H M, Gahrn-Hansen B, Kolmos H J, Schouenborg P, Korsager B, Tvede M, Gutschik E, Bremmelgaard A
Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark.
Eur J Clin Microbiol Infect Dis. 1995 Apr;14(4):275-81. doi: 10.1007/BF02116519.
The prevalence and antibiotic sensitivity patterns of bacteria collected consecutively from medical and surgical intensive care units (ICUs) and from hematology/oncology units in nine hospitals in Denmark were determined and compared to data collected simultaneously in 12 other European countries. Bacterial isolates from 794 Danish patients were tested and compared to 8,625 isolates from European patients. The minimal inhibitory concentrations of eight different antibiotics were determined using a microdilution plate. Similar to findings in European countries, the most common source of bacterial isolates in Danish units was the respiratory tract (49%), followed by blood (18%), urinary tract (14%) and surgical wounds (10%). Staphylococcus aureus was the most prevalent respiratory organism in Danish units, whereas Enterobacteriaceae and Pseudomonas aeruginosa dominated in other countries. In blood, Escherichia coli was most prevalent in Denmark while coagulase-negative staphylococci were predominant in other countries. Urinary tract isolates were dominated by Escherichia coli in both Denmark and the other countries, but Enterococcus faecalis and Pseudomonas aeruginosa were more frequently isolated in the other countries. Staphylococcus aureus was the most frequent wound isolate in Denmark, while Enterobacteriaceae other than Escherichia coli dominated in other European countries. Thus, in Denmark Escherichia coli and Staphylococcus aureus, followed by Pseudomonas aeruginosa and Klebsiella spp. (from ICUs) or Enterococcus spp. and Klebsiella spp. (from hematology/oncology units), are the most prominent pathogens in these units today. Indicator organisms of antibiotic consumption (Pseudomonas aeruginosa and methicillin-resistant coagulase-negative staphylococci and Staphylococcus aureus) were more frequent in other European countries than Denmark. In general the Danish isolates were more sensitive to antibiotics than the European isolates.(ABSTRACT TRUNCATED AT 250 WORDS)
对丹麦九家医院内科及外科重症监护病房（ICU）以及血液科/肿瘤科连续采集的细菌的流行情况和抗生素敏感性模式进行了测定，并与其他12个欧洲国家同时收集的数据进行比较。对来自794名丹麦患者的细菌分离株进行了检测，并与来自欧洲患者的8625株分离株进行比较。使用微量稀释板测定了八种不同抗生素的最低抑菌浓度。与欧洲国家的研究结果相似，丹麦各科室细菌分离株最常见的来源是呼吸道（49%），其次是血液（18%）、泌尿道（14%）和手术伤口（10%）。金黄色葡萄球菌是丹麦各科室最常见的呼吸道病原体，而肠杆菌科和铜绿假单胞菌在其他国家占主导地位。在血液中，丹麦最常见的是大肠杆菌，而凝固酶阴性葡萄球菌在其他国家占主导地位。丹麦和其他国家泌尿道分离株均以大肠杆菌为主，但粪肠球菌和铜绿假单胞菌在其他国家更常分离到。金黄色葡萄球菌是丹麦最常见的伤口分离株，而除大肠杆菌外的肠杆菌科在其他欧洲国家占主导地位。因此，在丹麦，大肠杆菌和金黄色葡萄球菌，其次是铜绿假单胞菌和克雷伯菌属（来自ICU）或肠球菌属和克雷伯菌属（来自血液科/肿瘤科），是目前这些科室中最突出的病原体。抗生素消费的指示菌（铜绿假单胞菌、耐甲氧西林凝固酶阴性葡萄球菌和金黄色葡萄球菌）在其他欧洲国家比丹麦更常见。总体而言，丹麦的分离株比欧洲的分离株对抗生素更敏感。（摘要截选至250词）
