Hayashi K, Noguchi N, Niki E
Research Center for Advanced Science and Technology (RCAST), University of Tokyo, Japan.
FEBS Lett. 1995 Aug 14;370(1-2):37-40. doi: 10.1016/0014-5793(95)00786-9.
To elucidate the protective role of nitric oxide (NO) against lipid peroxidation, the effect of NO donor on the formation of lipid hydroperoxide and consumption of alpha-tocopherol in the oxidation of soybean phosphatidylcholine liposomal membranes was studied. The oxidation was induced by either aqueous or lipophilic peroxyl radicals generated by the hydrophilic or lipophilic azo compound, respectively. It was found that NO acted as a potent antioxidant by scavenging peroxyl radicals rapidly. It was also found that NO was capable of penetrating multilamellar membranes to scavenge lipid peroxyl radicals and spare alpha-tocopherol.
为阐明一氧化氮（NO）对脂质过氧化的保护作用，研究了NO供体对大豆磷脂酰胆碱脂质体膜氧化过程中脂质氢过氧化物形成及α-生育酚消耗的影响。氧化反应分别由亲水性或亲脂性偶氮化合物产生的水性或亲脂性过氧自由基引发。结果发现，NO通过快速清除过氧自由基而起到强效抗氧化剂的作用。还发现NO能够穿透多层膜以清除脂质过氧自由基并节省α-生育酚。
