Kumar R M, Uduman S A, Khurranna A K
Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates.
Int J Gynaecol Obstet. 1995 May;49(2):137-43. doi: 10.1016/0020-7292(95)02356-h.
To study the impact of HIV-1 infection on pregnancy and maternal and early fetal outcome.
From January 1992 to January 1993, 160 HIV-1 seropositive women and 164 HIV-1 seronegative age- and parity-matched pregnant tribal women from Manipur, India, were recruited into a prospective study. Mother and infant were followed until 6 weeks postpartum.
Nine percent (15/160) of subjects had AIDS (CDC IV), 38% (60/160) were symptomatic (CDC III) and 53% (85/160) were asymptomatic (CDC I/II). Symptomatic (CDC III/IV) HIV-1 infection is associated with a significantly increased rate of miscarriage, low birth weight, intrauterine fetal death and preterm delivery. Perinatal, infant and maternal deaths were limited to symptomatic women. HIV-1 infected women were significantly younger than their HIV-1 negative counterparts both in age and age at sexual debut. Placental membrane inflammation was significantly higher in the seropositive group and this correlated well with a higher risk of preterm delivery and postpartum endometritis. Asymptomatic HIV-1 infection was not associated with adverse pregnancy outcome.
Symptomatic (CDC III/IV) HIV-1 infection in Indian tribal women is associated with adverse maternal and fetal outcome.
研究人类免疫缺陷病毒1型（HIV-1）感染对妊娠及孕产妇和早期胎儿结局的影响。
1992年1月至1993年1月，来自印度曼尼普尔邦的160名HIV-1血清反应阳性孕妇和164名年龄及胎次匹配的HIV-1血清反应阴性的部落孕妇被纳入一项前瞻性研究。对母亲和婴儿进行随访直至产后6周。
9%（15/160）的研究对象患有艾滋病（美国疾病控制与预防中心IV级），38%（60/160）有症状（美国疾病控制与预防中心III级），53%（85/160）无症状（美国疾病控制与预防中心I/II级）。有症状的（美国疾病控制与预防中心III/IV级）HIV-1感染与流产率、低出生体重、宫内胎儿死亡和早产率显著增加相关。围产期、婴儿及孕产妇死亡均限于有症状的女性。HIV-1感染的女性在年龄及首次性行为年龄方面均显著低于HIV-1阴性的女性。血清反应阳性组胎盘膜炎症显著更高，这与早产和产后子宫内膜炎的较高风险密切相关。无症状的HIV-1感染与不良妊娠结局无关。
印度部落女性中有症状的（美国疾病控制与预防中心III/IV级）HIV-1感染与不良孕产妇和胎儿结局相关。
