Klutke J J, Bergman A
Department of Obstetrics and Gynecology, Women's and Children's Hospital, USC School of Medicine, Los Angeles, USA.
Int J Gynaecol Obstet. 1995 May;49(2):171-4. doi: 10.1016/0020-7292(95)02339-e.
To evaluate the effect of alpha-interferon as an adjuvant to laser or fluorouracil treatment in patients with recurrent genital human papillomavirus (HPV) infection.
Sixty-two females and 21 males were treated for recurrent HPV infection, with either fluorouracil (Efudex 5%) cream or laser ablation of the lesions. Half of the patients were then randomly treated with adjuvant alpha-interferon, to the lesions for patients treated with fluorouracil, or beneath areas previously treated by laser, once a week, for 8 weeks. The other half of the patients did not receive interferon adjuvant. Evaluation of both groups was done using colposcopy and acetic acid, to assess recurrence rates up to 1 year after treatment.
Of the 83 patients followed for 1 year, colposcopy revealed recurrent anogenital lesions in 3 of 45 receiving interferon, compared with 9 of 38 patients treated without adjuvant interferon.
Interferon is effective as adjuvant treatment in controlling the recurrence of genital HPV.
评估α干扰素作为激光或氟尿嘧啶治疗复发性生殖器人乳头瘤病毒（HPV）感染患者辅助治疗手段的效果。
62名女性和21名男性接受复发性HPV感染治疗，采用氟尿嘧啶（5%艾氟迪）乳膏或对病变进行激光消融。然后，一半患者随机接受辅助性α干扰素治疗，对接受氟尿嘧啶治疗的患者，将干扰素涂抹于病变部位；对接受激光治疗的患者，将干扰素注射于先前接受激光治疗区域的下方，每周一次，共8周。另一半患者不接受干扰素辅助治疗。使用阴道镜和醋酸对两组患者进行评估，以评估治疗后长达1年的复发率。
在随访1年的83名患者中，阴道镜检查显示，45名接受干扰素治疗的患者中有3名出现复发性肛门生殖器病变，而38名未接受辅助干扰素治疗的患者中有9名出现复发性肛门生殖器病变。
干扰素作为辅助治疗手段在控制生殖器HPV复发方面有效。
