甲硝唑在阑尾切除术后预防和治疗拟杆菌感染中的应用
Metronidazole in prevention and treatment of bacteroides infections after appendicectomy.
作者信息
Willis A T, Ferguson I R, Jones P H, Phillips K D, Tearle P V, Berry R B, Fiddian R V, Graham D F, Harland D H, Innes D B, Mee W M, Rothwell-Jackson R L, Sutch I, Kilbey C, Edwards D
出版信息
Br Med J. 1976 Feb 7;1(6005):318-21. doi: 10.1136/bmj.1.6005.318.
Abstract
The frequency of non-clostridial anaerobic infection was studied in 95 patients who had undergone acute appendicectomy: 49 received prophylactic metronidazole and 46 received placebo. Anaerobic infection did not develop in any of the metronidazole-treated patients, but infections did develop in nine (19%) of the 46 controls. Metronidazole is conveniently administered by suppository to patients who cannot take oral drugs. Five patients with intra-abdominal infections caused by non-clostridial anaerobes were successfully treated with metronidazole.
摘要
对95例行急性阑尾切除术的患者的非梭菌性厌氧菌感染发生率进行了研究：49例接受了预防性甲硝唑治疗，46例接受了安慰剂治疗。接受甲硝唑治疗的患者均未发生厌氧菌感染，但46例对照组患者中有9例（19%）发生了感染。对于无法口服药物的患者，甲硝唑通过栓剂给药很方便。5例由非梭菌性厌氧菌引起的腹腔内感染患者用甲硝唑成功治愈。
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