Heimdahl A, Nord C E, Okuda K
Med Microbiol Immunol. 1980 Feb;168(1):1-10. doi: 10.1007/BF02121647.
Tinidazole in capsules was given orally in doses of 150 mg twice per day for 7 days to ten subjects. Saliva, throat, and faecal specimens were taken up to 16 days after administration for cultivation of aerobic and anaerobic bacteria and for assay of tinidazole. Mean peak serum levels of tinidazole varied between 3.3 microgram/ml to 5.4 microgram/ml. The saliva concentrations of tinidazole were between 2.9 microgram/ml to 5.9 microgram/ml. No concentration of tinidazole was detected in faeces. In saliva, a slight decrease in the numbers of fusobacteria was found, but no other changes in the oral, throat, or colon microflora were observed.
给10名受试者口服胶囊型替硝唑，剂量为150毫克，每日两次，共7天。给药后长达16天采集唾液、咽喉和粪便标本，用于需氧菌和厌氧菌培养以及替硝唑测定。替硝唑的平均血清峰值水平在3.3微克/毫升至5.4微克/毫升之间。替硝唑的唾液浓度在2.9微克/毫升至5.9微克/毫升之间。粪便中未检测到替硝唑浓度。在唾液中，发现梭杆菌数量略有减少，但未观察到口腔、咽喉或结肠微生物群的其他变化。
