Arai N, Shiomi K, Tomoda H, Tabata N, Yang D J, Masuma R, Kawakubo T, Omura S
Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
J Antibiot (Tokyo). 1995 Jul;48(7):696-702. doi: 10.7164/antibiotics.48.696.
New azaphilones named isochromophilones III-VI were isolated from the culture broth of Penicillium multicolor FO-3216 as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT). Their structures were elucidated by NMR and other spectroscopic analyses. The IC50 values of isochromophilones III, IV, V and VI for ACAT activity in an enzyme assay using rat liver microsomes were calculated to be 110, 50, 50 and 120 microM, respectively.
从多色青霉FO-3216的培养液中分离出了名为异嗜色菌素III-VI的新型氮杂环庚三烯酮，作为酰基辅酶A：胆固醇酰基转移酶（ACAT）的抑制剂。通过核磁共振（NMR）和其他光谱分析确定了它们的结构。在使用大鼠肝脏微粒体的酶测定中，异嗜色菌素III、IV、V和VI对ACAT活性的IC50值经计算分别为110、50、50和120微摩尔。
