Mitrushina M, Uchiyama C, Satz P
UCLA School of Medicine 90024-1759, USA.
J Clin Exp Neuropsychol. 1995 May;17(3):374-82. doi: 10.1080/01688639508405130.
This study explores the presence of homogeneous subgroups among 156 normal elderly subjects based on their performance on a battery of neuropsychological tests. Subjects ranged in age between 57 and 85 years and included 62 males and 94 females with a mean age 70.7 years, mean education 14.1 years, and mean Full Scale IQ of 117.2. Six clusters were extracted, three of which are likely to represent preclinical stages of the dementing process with distinct patterns of cognitive deficits. The results are discussed in light of different models of cognitive deterioration in DAT.
本研究基于156名正常老年人在一系列神经心理学测试中的表现，探讨了同质亚组的存在情况。受试者年龄在57岁至85岁之间，包括62名男性和94名女性，平均年龄70.7岁，平均受教育年限14.1年，平均全量表智商为117.2。提取了六个聚类，其中三个可能代表痴呆过程的临床前期阶段，具有不同的认知缺陷模式。根据不同的阿尔茨海默病认知衰退模型对结果进行了讨论。
