Ng E, Leader A, Claman P, Domingo M, Spence J E
Division of Gynecologic Reproductive Endocrinology and Infertility, University of Ottawa, Ottawa Civic Hospital, Ontario, Canada.
Hum Reprod. 1995 Apr;10(4):807-10. doi: 10.1093/oxfordjournals.humrep.a136043.
A cohort study was undertaken to compare the effect at the time of oocyte retrieval of the i.v. administration of either 1000 ml of lactated Ringer's solution or 1000 ml of a 5% solution of human albumin on in-vitro fertilization patients at risk for severe ovarian hyperstimulation syndrome (OHSS). A total of 207 patients with an oestradiol concentration > 10,000 pmol/l and/or > 15 follicles (> 10 mm diameter) on the day of human chorionic gonadotrophin (HCG) injection were reviewed. Of these, 158 women received 500 ml of lactated Ringer's solution both before and after egg retrieval, and 49 women received two infusions of 500 ml of 5% human albumin in normal saline at the time of egg retrieval. Severe OHSS developed in two patients who received human albumin and in 10 women who did not receive the albumin. This difference was not statistically significant. There were no differences between the two groups in terms of age, number of follicles punctured at transvaginal oocyte retrieval or oestradiol concentration at the time of HCG injection. The administration of a 5% human albumin solution does not prevent the development of severe OHSS in at risk patients. It does appear to blunt the severity of the condition.
开展了一项队列研究，以比较静脉输注1000毫升乳酸林格氏液或1000毫升5%人白蛋白溶液对有严重卵巢过度刺激综合征（OHSS）风险的体外受精患者在取卵时的影响。对总共207例在注射人绒毛膜促性腺激素（HCG）当天雌二醇浓度>10,000 pmol/l和/或有>15个卵泡（直径>10毫米）的患者进行了评估。其中，158名女性在取卵前后均接受了500毫升乳酸林格氏液，49名女性在取卵时接受了两次500毫升5%人白蛋白生理盐水输注。接受人白蛋白的两名患者和未接受白蛋白的10名女性发生了严重OHSS。这种差异无统计学意义。两组在年龄、经阴道取卵时穿刺的卵泡数量或注射HCG时的雌二醇浓度方面无差异。5%人白蛋白溶液的输注并不能预防有风险患者发生严重OHSS。但它似乎确实能减轻病情的严重程度。
