静脉注射白蛋白可预防体外受精患者发生中重度卵巢过度刺激：一项前瞻性、随机对照研究。
Intravenous albumin prevents moderate-severe ovarian hyperstimulation in in-vitro fertilization patients: a prospective, randomized and controlled study.
作者信息
Isik A Z, Gokmen O, Zeyneloglu H B, Kara S, Keles G, Gulekli B
机构信息
Reproductive Endocrinology and IVF Unit, Dr. Zekai Tahir Burak Women's Hospital, Ankara, Turkey.
出版信息
Eur J Obstet Gynecol Reprod Biol. 1996 Dec 27;70(2):179-83. doi: 10.1016/s0301-2115(95)02603-7.
OBJECTIVE
To assess the effectiveness of intravenous administration of albumin in prevention of ovarian hyperstimulation syndrome (OHSS) in patients of an in-vitro fertilization program.
STUDY DESIGN
Prospective randomized study. Patients with hCG day E2 levels are 11010 pmol/l (3000 pg/ml) or more were recruited into two groups. Group A (n = 27) received 10 g 20%, 50 ml human albumin infusion before oocyte pick-up and no medication was administered in Group B (n = 28).
RESULTS
Patients were similar in terms of cycle characteristics. No moderate-severe OHSS developed in Group A whereas one severe OHSS case and four moderate OHSS cases developed in Group B. Statistical analysis revealed a significant (P < 0.05) protection in albumin treated group.
CONCLUSION
Human albumin proves effectiveness in prevention of moderate-severe OHSS.
目的
评估静脉注射白蛋白对体外受精项目患者预防卵巢过度刺激综合征（OHSS）的有效性。
研究设计
前瞻性随机研究。将人绒毛膜促性腺激素（hCG）日雌二醇（E2）水平为11010皮摩尔/升（3000皮克/毫升）或更高的患者分为两组。A组（n = 27）在取卵前接受10克20%、50毫升人白蛋白输注，B组（n = 28）不给予药物治疗。
结果
两组患者的周期特征相似。A组未发生中度至重度OHSS，而B组发生1例重度OHSS病例和4例中度OHSS病例。统计分析显示白蛋白治疗组有显著（P < 0.05）的保护作用。
结论
人白蛋白在预防中度至重度OHSS方面证明有效。
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