感染伯氏疟原虫的大鼠脾脏细胞中胸苷掺入的动力学
Dynamics of thymidine incorporation by spleen cells from rats infected with Plasmodium berghei.
作者信息
Golenser J, Spira D T, Zuckerman A
出版信息
Clin Exp Immunol. 1975 Nov;22(2):364-71.
Abstract
The in vitro incorporation of thymidine by spleen cells of rat infected with Plasmodium berghei was higher than that of normal rat spleen cells. The incorporation was proportional to the number of cells in the system and was related to the day of infection, e.g. spleen cells from malarious rats incorporated up to forty times as much thymidine as did normal spleen cells 21 days after inoculation. At the same time, the response of the malarious spleen cells to phytohaemagglutinin (PHA) was only one-twentieth of that observed for normal spleen cells. The thymidine was incorporated by non-adherent spleen cells in a single pulse during the first 8 hr in culture.
摘要
感染伯氏疟原虫的大鼠脾脏细胞在体外对胸苷的掺入量高于正常大鼠脾脏细胞。掺入量与体系中的细胞数量成正比，且与感染天数有关，例如，接种后21天，疟疾病大鼠的脾脏细胞掺入的胸苷量高达正常脾脏细胞的40倍。同时，疟疾病脾脏细胞对植物血凝素（PHA）的反应仅为正常脾脏细胞的二十分之一。在培养的前8小时内，非贴壁脾脏细胞在单次脉冲中掺入胸苷。
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本文引用的文献
1
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Nature. 1964 Sep 26;203:1366-7. doi: 10.1038/2031366a0.
2
Blood loss and replacement in plasmodial infections. I. Plasmodium berghei in untreated rats of varying age and in adult rats with erythropoietic mechanisms manipulated before inoculation.疟原虫感染中的失血与补充。I. 不同年龄未治疗大鼠及接种前红细胞生成机制被操控的成年大鼠体内的伯氏疟原虫。
J Infect Dis. 1957 Mar-Apr;100(2):172-206. doi: 10.1093/infdis/100.2.172.
3
Anaemia and erythropoiesis in the irradiated rat: an experimental study with particular reference to techniques involving radioactive iron.
Br J Haematol. 1955 Jan;1(1):86-103. doi: 10.1111/j.1365-2141.1955.tb05491.x.
4
The cellular reactions to infections with Plasmodium berghei in the white mouse.小白鼠对伯氏疟原虫感染的细胞反应。
J Infect Dis. 1954 May-Jun;94(3):241-61. doi: 10.1093/infdis/94.3.241.
5
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Exp Parasitol. 1970 Jun;27(3):479-95. doi: 10.1016/0014-4894(70)90052-4.
6
Spontaneous lymphocyte transformation in leucocyte cultures of children with falciparum malaria.
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7
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8
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