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鼠疟中的特异性淋巴细胞转化

Specific lymphocyte transformation in murine malaria.

作者信息

Golenser J, Spira D T, Verhave J P, Meuwissen J H

出版信息

Z Parasitenkd. 1976 Jul 27;50(1):95-8. doi: 10.1007/BF00389938.

DOI:10.1007/BF00389938
PMID:785850
Abstract

Lymphoblast transformation tests were performed on convalescent rats and mice, after infection with Plasmodium berghei had been reduced to latency. Spleen cells from immune animals reacted in vitro to specific plasmodial antigen and not to control antigen produced from non infected RBC. The response in vitro was dependent on the concentration of the antigen and the time of exposure to it. A correlation was observed between the parasitaemia of the convalescent animal during its acute infection and the reaction in vitro: the higher the parasitaemia the higher the in vitro simulation.

摘要

在用伯氏疟原虫感染降至潜伏期后,对恢复期大鼠和小鼠进行了淋巴细胞转化试验。免疫动物的脾细胞在体外对特定疟原虫抗原产生反应,而对未感染红细胞产生的对照抗原无反应。体外反应取决于抗原浓度和暴露于抗原的时间。观察到恢复期动物急性感染期间的寄生虫血症与体外反应之间存在相关性:寄生虫血症越高,体外模拟反应越高。

相似文献

1
Specific lymphocyte transformation in murine malaria.鼠疟中的特异性淋巴细胞转化
Z Parasitenkd. 1976 Jul 27;50(1):95-8. doi: 10.1007/BF00389938.
2
Lymphoblast transformation in rats convalescent from infection with Plasmodium berghei.感染伯氏疟原虫后康复的大鼠中的淋巴细胞转化
Isr J Med Sci. 1978 May;14(5):590-5.
3
An in vitro assay for T cell immunity to malaria in mice.一种针对小鼠疟疾T细胞免疫的体外检测方法。
J Immunol. 1976 May;116(5):1280-3.
4
Lipid antigens derived from erythrocytes infected with Plasmodium berghei.源自感染伯氏疟原虫的红细胞的脂质抗原。
Z Parasitenkd. 1984;70(3):331-6. doi: 10.1007/BF00927819.
5
Antigen-specific and concanavalin A-induced lymphocyte blastogenesis responses during the course of Plasmodium berghei infection in rats.大鼠感染伯氏疟原虫过程中的抗原特异性及伴刀豆球蛋白A诱导的淋巴细胞增殖反应
Parasite Immunol. 1984 Sep;6(5):435-42. doi: 10.1111/j.1365-3024.1984.tb00814.x.
6
Activation and exhaustion of antigen-specific CD8 T cells occur in different splenic compartments during infection with Plasmodium berghei.在感染伯氏疟原虫期间,抗原特异性CD8 T细胞的激活和耗竭发生在脾脏的不同区域。
Parasitol Int. 2017 Jun;66(3):227-235. doi: 10.1016/j.parint.2017.01.022. Epub 2017 Feb 3.
7
Perinatal immune priming in malaria: antigen-induced blastogenesis and adoptive transfer of resistance by splenocytes from rats born of Plasmodium berghei infected females.疟疾围产期免疫致敏:伯氏疟原虫感染雌性大鼠所产仔鼠脾细胞的抗原诱导母细胞形成及抗性的过继转移
Parasite Immunol. 1985 Jul;7(4):451-6. doi: 10.1111/j.1365-3024.1985.tb00090.x.
8
T-cell activation in murine malaria.小鼠疟疾中的T细胞激活
Nature. 1975 Nov 13;258(5531):149-51. doi: 10.1038/258149a0.
9
Soluble antigens released in vitro from erythrocytes infected with Plasmodium berghei.从感染伯氏疟原虫的红细胞体外释放的可溶性抗原。
Bull World Health Organ. 1979;57 Suppl 1(Suppl):83.
10
Adoptive transfer of immunity to Plasmodium berghei by a population of immune rat spleen cells resistant to cyclophosphamide.通过一群对环磷酰胺有抗性的免疫大鼠脾细胞将对伯氏疟原虫的免疫力进行过继转移。
Int J Parasitol. 1976 Apr;6(2):103-6. doi: 10.1016/0020-7519(76)90063-1.

本文引用的文献

1
Immunity to malaria. 3. Possible occurrence of a cell-mediated immunity to Plasmodium knowlesi in chronically infected and Freund's complete adjuvant-sensitized monkeys.对疟疾的免疫力。3. 慢性感染且经弗氏完全佐剂致敏的猴子中可能存在对诺氏疟原虫的细胞介导免疫。
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Blastoid transformation of lymphocytes in falciparum malaria.
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4
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Clin Exp Immunol. 1974 Aug;17(4):647-56.
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Lymphocyte transformation in human Plasmodium falciparum malaria.
J Immunol. 1974 Aug;113(2):449-54.
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The immunologic significance of antigen induced lymphocyte transformation in vitro.抗原诱导的淋巴细胞体外转化的免疫学意义。
J Immunol. 1966 Aug;97(2):239-47.
7
Dynamics of thymidine incorporation by spleen cells from rats infected with Plasmodium berghei.感染伯氏疟原虫的大鼠脾脏细胞中胸苷掺入的动力学
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