肝移植与甲型血友病

Liver transplantation and haemophilia A.

作者信息

Lerut J P, Laterre P F, Lavenne-Pardonge E, Donataccio M, Geubel A, Reynaert M S, Otte J B

机构信息

Department of Digestive Surgery, University Hospitals St. Luc, Catholic University of Louvain, Medical School, Brussels, Belgium.

出版信息

J Hepatol. 1995 May;22(5):583-5. doi: 10.1016/0168-8278(95)80454-4.

DOI:10.1016/0168-8278(95)80454-4

PMID:7650339

Abstract

Liver transplantation has become the standard treatment for a variety of inherited metabolic disorders. We report on two patients who underwent successful transplantation for posthepatitis viral cirrhosis, which developed following blood factor replacement for haemophilia A. The second patient was transplanted before the occurrence of major complications of either his liver or haemophilic disease. We propose early liver transplantation to achieve metabolic cure of haemophilia.

摘要

肝移植已成为多种遗传性代谢紊乱的标准治疗方法。我们报告了两名因甲型血友病血液因子替代治疗后发生的病毒性肝炎后肝硬化而接受成功移植的患者。第二名患者在其肝脏或血友病的主要并发症出现之前就接受了移植。我们建议早期进行肝移植以实现血友病的代谢治愈。