Wolfla C, Jacobson L
Department of Surgery, Indiana University Medical Center in Indianapolis, USA.
Indiana Med. 1995 Jul-Aug;88(4):282-5.
A 21-year-old white man was admitted with a diagnosis of mixed cellularity Hodgkin's lymphoma for staging laparotomy. His family history was positive for a brother who had both Hodgkin's lymphoma and atypical pseudocholinesterase. Serum pseudocholinesterase activity, dibucaine number and fluoride number were obtained, revealing markedly decreased pseudocholinesterase activity and dibucaine number, with an only slightly decreased fluoride number, consistent with homozygous type E1a atypical pseudocholinesterase. After induction of anesthesia using vecuronium, a staging laparotomy was performed without complication. Through a discussion of what is known of the genetics of Hodgkin's disease and atypical pseudocholinesterase, we conclude that the association between the two conditions is very rare but more likely due to chance than to genetic linkage.
一名21岁的白人男性因混合细胞型霍奇金淋巴瘤行分期剖腹术而入院。他的家族史显示，其兄长患有霍奇金淋巴瘤和非典型假性胆碱酯酶，家族史呈阳性。检测了血清假性胆碱酯酶活性、地布卡因值和氟化物值，结果显示假性胆碱酯酶活性和地布卡因值明显降低，而氟化物值仅略有降低，符合纯合子E1a型非典型假性胆碱酯酶。使用维库溴铵诱导麻醉后，进行了分期剖腹术，未出现并发症。通过对霍奇金病和非典型假性胆碱酯酶遗传学知识的讨论，我们得出结论，这两种疾病之间的关联非常罕见，更可能是偶然因素而非基因连锁所致。
