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[乳腺癌放射外科治疗后遗症的血管病专家管理]

[Management by the angiologist of sequellae of radiosurgical treatment of breast cancer].

作者信息

Gruffaz J

出版信息

J Mal Vasc. 1995;20(2):150-2.

PMID:7650444
Abstract

Often called in to give his opinion on lymphoedema of the upper limb after radiosurgical treatment for breast cancer, the angiologist should be familiar with the anatomic lesions induced by the treatment. The surgical procedure varies from simple tumourectomy to complete mammectomy. Complications include infection followed by fibrosis and occlusion of the collecting lymphatic vessels. Axillary venous thrombosis is exceptional. Dissection of the lymph nodes interrupts lymph drainage of the homolateral limb leading to lymphoedema which is worsened by fibrosis, venous stasis and damage to the plexus. Ionization therapy causes multiple organ damage to viscera (lungs, pleura), skeleton (ribs, clavicle), myocardium and coronary arteries, mediastinal brachial plexus, skin fibrosis, arterial obliteration and venous narrowing and thrombosis. Chemotherapy causes thrombosis of the superficial veins after perfusion. Deep vein thrombosis is rare. These lesions rarely occur alone. The clinical course of the associated lesions is part of a major psychological context which must be taken into account. The angiologist should perform a careful clinical examination, detect and document possible recurrence, explore the vascular axes with echo-Doppler or plethysmography when needed in order to detect the venous lesions which occur in 50% of the cases. Lymphatic involvement in lymphoedema is clinically obvious and may not require further explorations. Treatment is difficult in cases with associated venous involvement. Strapping with or without pressure, manual lymphatic drainage, active mobilisation and elastic sleave after reduction are used. When detected early venous thrombosis is managed as other deep vein thrombosis. Arterial damage may appear late (delay more than 3 years) in rare cases.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

血管病专家经常受邀就乳腺癌放射外科治疗后上肢淋巴水肿发表意见,因此应熟悉该治疗引发的解剖学病变。手术程序从单纯肿瘤切除术到全乳切除术不等。并发症包括感染,继而出现纤维化以及集合淋巴管闭塞。腋静脉血栓形成较为罕见。淋巴结清扫会中断同侧上肢的淋巴引流,导致淋巴水肿,而纤维化、静脉淤滞和神经丛损伤会使病情加重。电离疗法会对多个器官造成损害,包括内脏(肺、胸膜)、骨骼(肋骨、锁骨)、心肌和冠状动脉、纵隔臂丛神经、皮肤纤维化、动脉闭塞以及静脉狭窄和血栓形成。化疗会在灌注后导致浅静脉血栓形成。深静脉血栓形成较为罕见。这些病变很少单独出现。相关病变的临床过程是一个重要心理背景的一部分,必须予以考虑。血管病专家应进行仔细的临床检查,检测并记录可能的复发情况,必要时使用超声多普勒或体积描记法探查血管轴,以检测出50%病例中出现的静脉病变。淋巴水肿中的淋巴管受累在临床上很明显,可能无需进一步探查。伴有静脉受累的病例治疗困难。采用加压或不加压包扎、手动淋巴引流、主动活动以及消肿后使用弹力袖套等方法。早期发现静脉血栓形成时,按其他深静脉血栓形成进行处理。在罕见情况下,动脉损伤可能出现较晚(延迟超过3年)。(摘要截选至250词)

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