Yapar E G, Gökmen O
Department of Obstetrics and Gynecology, Doctor Zekai Tahir Burak Women's Hospital, Ankara, Turkey.
J Reprod Med. 1995 Jun;40(6):423-6.
The clinical performance of three rapidly performed tests--tap test, TDx Fetal Lung Maturity and amniotic fluid absorbance at 650 nm--in predicting fetal lung maturity were evaluated in 300 samples of clear amniotic fluid. In all cases, delivery occurred within three days of sample collection. Of the 300 newborns, 44 developed respiratory distress syndrome. For the tap test, the sensitivity (95.4%), specificity (82.8%), and predictive value for maturity (99.7%) and immaturity (48.9%) were comparable to those of the TDx fetal lung maturity test: sensitivity of 100%, specificity of 88.3%, and predictive value for maturity of 100% and immaturity of 53.1%. The specificity (68.4%) and predictive value for immaturity (34.7%) of amniotic fluid absorbance at 650 nm were significantly lower than for the TDx and tap tests, whereas no significant difference was found for sensitivity and prediction of maturity between amniotic fluid absorbance at 650 nm and the TDx and tap tests. Both the tap and the TDx tests appear to be useful in antenatal assessment of fetal lung maturity in terms of reliability, rapidity and uniformity.
在300份清亮羊水样本中评估了三种快速检测方法——轻拍试验、TDx胎儿肺成熟度检测和650nm波长下羊水吸光度——预测胎儿肺成熟度的临床性能。所有病例均在采集样本后三天内分娩。300例新生儿中，44例发生呼吸窘迫综合征。对于轻拍试验，其敏感性（95.4%）、特异性（82.8%）以及成熟度预测值（99.7%）和未成熟度预测值（48.9%）与TDx胎儿肺成熟度检测相当：敏感性为100%，特异性为88.3%，成熟度预测值为100%，未成熟度预测值为53.1%。650nm波长下羊水吸光度的特异性（68.4%）和未成熟度预测值（34.7%）显著低于TDx检测和轻拍试验，而650nm波长下羊水吸光度与TDx检测和轻拍试验在敏感性和成熟度预测方面未发现显著差异。就可靠性、快速性和一致性而言，轻拍试验和TDx检测在产前评估胎儿肺成熟度方面似乎都很有用。
