Elliott J P, Radin T G
Division of Maternal-Fetal Medicine, Good Samaritan Regional Medical Center, Phoenix, Arizona, USA.
J Reprod Med. 1995 Jun;40(6):450-2.
The objective of this study was to determine the serum levels of magnesium associated with various intravenous infusion rates of magnesium sulfate (MgSO4) in high-order multiple gestations. A retrospective review of 12 triplet and 4 quadruplet pregnancies cared for in Phoenix from August 1988 to January 1992 was performed. The mothers received MgSO4 for tocolysis of preterm labor. Serum magnesium levels were drawn to help manage patients with symptoms of an excessive magnesium level or an inadequate tocolytic effect. The results are presented for triplets and quadruplets with and without pregnancy-induced hypertension (PIH). The serum levels of Mg++ in triplets and quadruplets were similar to those in singleton pregnancies described in the literature. Higher serum levels of Mg++(7.0-7.5 mg/dL) seemed to be necessary for successful tocolysis. Serum levels of Mg++ in patients with underlying PIH were significantly higher at the same intravenous infusion rate. MgSO4 may need to be administered at infusion rates of 4-5 g/h to achieve therapeutic levels in women with triplets and quadruplets. PIH should require lower infusion rates to achieve therapeutic serum levels of Mg++.
本研究的目的是确定在多胎妊娠中，与不同静脉输注速率硫酸镁（MgSO4）相关的血清镁水平。对1988年8月至1992年1月在凤凰城接受治疗的12例三胎妊娠和4例四胎妊娠进行了回顾性研究。母亲们接受MgSO4用于早产的宫缩抑制。检测血清镁水平以帮助处理镁水平过高或宫缩抑制效果不佳症状的患者。给出了有和没有妊娠高血压综合征（PIH）的三胎和四胎妊娠的结果。三胎和四胎妊娠的Mg++血清水平与文献中描述的单胎妊娠相似。较高的Mg++血清水平（7.0 - 7.5mg/dL）似乎是成功进行宫缩抑制所必需的。在相同静脉输注速率下，患有潜在PIH的患者的Mg++血清水平显著更高。对于三胎和四胎妊娠的女性，可能需要以4 - 5g/h的输注速率给予MgSO4以达到治疗水平。PIH患者应需要较低的输注速率以达到Mg++的治疗性血清水平。
