Parente J T, Levy J, Chinea F, Espinosa B, Brescia M J
Department of Obstetrics and Gynecology, Bronx-Lebanon Hospital Center, New York 10457, USA.
J Reprod Med. 1995 Jun;40(6):468-70.
Leiomyomatosis peritonealis disseminata (LPD) is a rare condition that usually presents during pregnancy or in women during the reproductive years and who are taking oral contraceptives. An unusual case of extensive LPD occurred in a 39-year-old woman who was not pregnant and had never taken oral contraceptives. The condition was treated successfully with total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy, limited debulking and adjuvant hormonal therapy with megestrol acetate. Complete, rapid remission of residual tumor occurred in two months, as substantiated by clinical examination and serial sonography and laparoscopy. This is the first time that adjuvant hormonal therapy has been used successfully in the treatment of LPD. Radical surgery in patients with LPD is probably not indicated, and the use of adjuvant hormonal therapy may accelerate regression of residual tumor. Further evaluation of this form of therapy is recommended.
播散性腹膜平滑肌瘤病（LPD）是一种罕见疾病，通常在孕期或处于生育年龄且正在服用口服避孕药的女性中出现。一名39岁未孕且从未服用过口服避孕药的女性发生了一例罕见的广泛性LPD。通过全腹子宫切除术、双侧输卵管卵巢切除术、大网膜切除术、有限的肿瘤减灭术以及醋酸甲地孕酮辅助激素治疗，该疾病得到了成功治疗。临床检查、系列超声检查和腹腔镜检查证实，残余肿瘤在两个月内完全、迅速缓解。这是首次成功使用辅助激素治疗LPD。对于LPD患者，可能不适合进行根治性手术，使用辅助激素治疗可能会加速残余肿瘤的消退。建议对这种治疗方式进行进一步评估。
