2,3-丁二酮一肟（BDM）可提高离体心肌细胞的初始产量并改善其长期存活率。
2,3-Butanedione monoxime (BDM) increases initial yields and improves long-term survival of isolated cardiac myocytes.
作者信息
Kivistö T, Mäkiranta M, Oikarinen E L, Karhu S, Weckström M, Sellin L C
机构信息
Department of Physical Sciences, University of Oulu, Finland.
出版信息
Jpn J Physiol. 1995;45(1):203-10. doi: 10.2170/jjphysiol.45.203.
PMID:7650854
Abstract
When BDM is added to the perfusion solutions used during the preparation of single, enzymatically dispersed mammalian cardiomyocytes, higher yields of calcium-tolerant cells are obtained. As the principal component of a storage solution, BDM also improves the survival of myocytes maintained in cold storage. These data support the hypothesis that BDM can act as a cardioprotective agent under certain conditions.
摘要
当将2,3-丁二酮一肟（BDM）添加到制备单个酶分散哺乳动物心肌细胞过程中使用的灌注溶液中时，可获得更高产量的耐钙细胞。作为保存溶液的主要成分，BDM还可提高冷藏心肌细胞的存活率。这些数据支持了BDM在某些条件下可作为心脏保护剂的假说。
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