McGuire P K, Silbersweig D A, Wright I, Murray R M, David A S, Frackowiak R S, Frith C D
Department of Psychological Medicine, Institute of Psychiatry, London, UK.
Lancet. 1995 Sep 2;346(8975):596-600. doi: 10.1016/s0140-6736(95)91435-8.
Auditory verbal hallucinations ("voices") are thought to arise from a disorder of inner speech (thinking in words). We examined the neural correlates of tasks which involve inner speech in subjects with schizophrenia who hear voices (hallucinators), subjects with schizophrenia who do not (nonhallucinators), and normal controls. There were no differences between hallucinators and controls in regional cerebral blood flow during thinking in sentences. However, when imagining sentences being spoken in another person's voice--which entails both the generation and monitoring of inner speech--hallucinators had a normal left frontal response, but reduced activation in the left middle temporal gyrus and the rostral supplementary motor area, regions which were activated by both normal subjects and nonhallucinators (p < 0.001). These findings suggest that a predisposition to verbal hallucinations is associated with a failure to activate areas concerned with the monitoring of inner speech.
听幻觉（“幻听”）被认为源于内部言语（言语性思维）障碍。我们研究了涉及内部言语的任务在有幻听的精神分裂症患者（幻觉者）、无幻听的精神分裂症患者（非幻觉者）和正常对照者中的神经关联。在进行句子思维时，幻觉者与对照者之间的局部脑血流没有差异。然而，当想象句子以他人声音说出时——这需要内部言语的生成和监测——幻觉者左侧额叶反应正常，但左侧颞中回和嘴侧辅助运动区的激活减少，而正常受试者和非幻觉者在这些区域均有激活（p < 0.001）。这些发现表明，言语性幻觉的易感性与未能激活与内部言语监测相关的区域有关。
