脂质介导的a因子与人工膜的相互作用。

Lipid-mediated a-factor interactions with artificial membranes.

作者信息

Epand R M, Naider F, Becker J M

机构信息

Department of Biochemistry, McMaster University Health Sciences Center, Hamilton, Ontario, Canada.

出版信息

Methods Enzymol. 1995;250:169-86. doi: 10.1016/0076-6879(95)50071-5.

DOI:10.1016/0076-6879(95)50071-5

PMID:7651149

Abstract

Our understanding of the cellular export of a-factor and its interaction with the receptor do not yet allow for a description of the phenomena on a molecular level. Synthesis of a-factor analogs and biophysical studies of the lipopeptides in the presence of artificial membranes provide insights which can be analyzed with respect to the biological potency of the molecules. It is through the study of the interaction of the lipopeptides with membranes at varying levels of complexity that we will be able to develop a molecular description of the biological processes.

摘要

我们对α-因子的细胞输出及其与受体相互作用的理解，目前还无法在分子水平上描述这些现象。α-因子类似物的合成以及在人工膜存在下对脂肽的生物物理研究提供了一些见解，这些见解可根据分子的生物活性进行分析。正是通过研究脂肽与不同复杂程度膜的相互作用，我们才能够对生物过程进行分子描述。