Functional significance of myristoyl moiety in N-myristoyl proteins.

作者信息

Knoll L J, Johnson D R, Bryant M L, Gordon J I

机构信息

Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

出版信息

Methods Enzymol. 1995;250:405-35. doi: 10.1016/0076-6879(95)50088-x.

DOI:10.1016/0076-6879(95)50088-x

PMID:7651168

Abstract

摘要

相似文献

Functional significance of myristoyl moiety in N-myristoyl proteins.

Methods Enzymol. 1995;250:405-35. doi: 10.1016/0076-6879(95)50088-x.

Use of Escherichia coli strains containing fad mutations plus a triple plasmid expression system to study the import of myristate, its activation by Saccharomyces cerevisiae acyl-CoA synthetase, and its utilization by S. cerevisiae myristoyl-CoA:protein N-myristoyltransferase.利用含有脂肪酸去饱和酶（fad）突变的大肠杆菌菌株以及三重质粒表达系统来研究肉豆蔻酸的导入、其被酿酒酵母酰基辅酶A合成酶激活的过程，以及其被酿酒酵母肉豆蔻酰辅酶A：蛋白质N-肉豆蔻酰转移酶利用的情况。

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Myristoylation and ADP-ribosylation factor function.肉豆蔻酰化与 ADP 核糖基化因子功能

Methods Enzymol. 1995;250:394-405. doi: 10.1016/0076-6879(95)50087-1.

The substrate specificity of Saccharomyces cerevisiae myristoyl-CoA: protein N-myristoyltransferase. Polar probes of the enzyme's myristoyl-CoA recognition site.酿酒酵母肉豆蔻酰辅酶A：蛋白质N-肉豆蔻酰转移酶的底物特异性。该酶肉豆蔻酰辅酶A识别位点的极性探针。

J Biol Chem. 1994 Feb 18;269(7):5346-57.

Genetic and biochemical studies of a mutant Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase, nmt72pLeu99-->Pro, that produces temperature-sensitive myristic acid auxotrophy.对一种突变型酿酒酵母肉豆蔻酰辅酶A：蛋白质N-肉豆蔻酰转移酶nmt72pLeu99→Pro进行的遗传和生化研究，该突变酶产生温度敏感型肉豆蔻酸营养缺陷型。

J Biol Chem. 1993 Jan 5;268(1):483-94.

Myristoylation of G-protein alpha subunits.G蛋白α亚基的肉豆蔻酰化

Methods Enzymol. 1994;237:254-68. doi: 10.1016/s0076-6879(94)37067-2.

Substrate specificity of Saccharomyces cerevisiae myristoyl-CoA: protein N-myristoyltransferase. Analysis of fatty acid analogs containing carbonyl groups, nitrogen heteroatoms, and nitrogen heterocycles in an in vitro enzyme assay and subsequent identification of inhibitors of human immunodeficiency virus I replication.酿酒酵母肉豆蔻酰辅酶A：蛋白质N-肉豆蔻酰转移酶的底物特异性。在体外酶测定中分析含有羰基、氮杂原子和氮杂环的脂肪酸类似物，并随后鉴定人类免疫缺陷病毒I复制的抑制剂。

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Palmitoylation of G-protein alpha subunits.G蛋白α亚基的棕榈酰化作用。

Methods Enzymol. 1995;250:314-30. doi: 10.1016/0076-6879(95)50081-2.

Comparison of the acyl chain specificities of human myristoyl-CoA synthetase and human myristoyl-CoA:protein N-myristoyltransferase.人肉豆蔻酰辅酶A合成酶与人肉豆蔻酰辅酶A：蛋白质N-肉豆蔻酰转移酶的酰基链特异性比较。

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Studies of the catalytic activities and substrate specificities of Saccharomyces cerevisiae myristoyl-coenzyme A: protein N-myristoyltransferase deletion mutants and human/yeast Nmt chimeras in Escherichia coli and S. cerevisiae.酿酒酵母肉豆蔻酰辅酶A：蛋白质N-肉豆蔻酰转移酶缺失突变体以及人/酵母Nmt嵌合体在大肠杆菌和酿酒酵母中的催化活性和底物特异性研究

J Biol Chem. 1992 Nov 25;267(33):23852-61.

引用本文的文献

Tool box: Plasmids for the expression or knockdown of human ARF Family GTPases (ARF/ARL/SAR) and their co-expression in bacteria with N-myristoyltransferases.工具盒：用于表达或敲低人ARF家族GTP酶（ARF/ARL/SAR）的质粒，以及它们与N-肉豆蔻酰转移酶在细菌中的共表达。

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N-myristoyltransferase is a cell wall target in Aspergillus fumigatus.N-肉豆蔻酰转移酶是烟曲霉细胞壁的一个靶点。

ACS Chem Biol. 2015 Jun 19;10(6):1425-34. doi: 10.1021/cb5008647. Epub 2015 Feb 27.

N-myristoylated proteins, key components in intracellular signal transduction systems enabling rapid and flexible cell responses.N-豆蔻酰化蛋白是细胞内信号转导系统的关键组成部分，使细胞能够快速灵活地做出反应。

Proc Jpn Acad Ser B Phys Biol Sci. 2010;86(5):494-508. doi: 10.2183/pjab.86.494.

Homology modeling and molecular dynamics simulation of N-myristoyltransferase from protozoan parasites: active site characterization and insights into rational inhibitor design.原生动物寄生虫N-肉豆蔻酰转移酶的同源建模与分子动力学模拟：活性位点表征及合理抑制剂设计的见解

J Comput Aided Mol Des. 2009 Jun;23(6):375-89. doi: 10.1007/s10822-009-9267-2. Epub 2009 Apr 16.

Acyl-CoA binding proteins: multiplicity and function.酰基辅酶A结合蛋白：多样性与功能

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