Savage J R
MRC Radiobiology Unit, Chilton, Didcot, UK.
Mutat Res. 1995 Jul;347(2):87-95. doi: 10.1016/0165-7992(95)90075-6.
The first 26 families of complex chromosome-type exchanges (from three breaks in two chromosomes to five breaks in five chromosomes) have been evaluated, and the 15,060 exchanges resulting from unrestricted restitution or rejoining of the break ends yields 203 distinctive patterns, if a single participating chromosome is FISH-painted. If we assume that any exchange that produces an acentric fragment of any sort (compound-terminal or interstitial) will be ultimately eliminated in a continuously dividing cell population, then, irrespective of family origin, only 17 of these patterns (approximately 8%) will be transmitted, long-term. The 17 are illustrated, and the implications briefly discussed.
已经对最初的26个复杂染色体类型交换家族（从两条染色体中的三个断裂到五条染色体中的五个断裂）进行了评估，如果对单个参与的染色体进行荧光原位杂交（FISH）标记，那么由断裂末端的无限制恢复或重新连接产生的15,060次交换会产生203种独特模式。如果我们假设任何产生任何类型无着丝粒片段（复合末端或中间型）的交换在连续分裂的细胞群体中最终都会被消除，那么，无论家族起源如何，这些模式中只有17种（约8%）会长期传递下去。文中展示了这17种模式，并简要讨论了其意义。
