Törnhage C J, Serenius F, Uvnäs-Moberg K, Lindberg T
Department of Pediatrics, Umeå University, Sweden.
Pediatr Res. 1995 Jun;37(6):771-6. doi: 10.1203/00006450-199506000-00016.
Regulatory gut peptides play an important role in regulating the gastrointestinal tract. Our knowledge about the pattern of secretion and function of these peptides is scanty in preterm infants. Therefore, plasma somatostatin (SS) and cholecystokinin (CCK) levels were estimated just after birth in 65 mothers and 73 preterm infants (umbilical cord blood). The gestational age was 32 (24-36 median ranges) wk and birth weight 1900 (475-3350) g. The umbilical cord blood pH was 7.32 +/- 0.10 (mean +/- SD). After Sep-Pak-C18 semichromatography of plasma, SS and CCK were analyzed by RIA. Both plasma SS and CCK levels were significantly higher in infants than in mothers (SS = 14.5 +/- 12.4 versus 9.3 +/- 7.6 pmol/L; CCK = 11.6 +/- 7.4 versus 7.0 +/- 1.9 pmol/L). In appropriate for gestational age and small for gestational age infants' plasma levels of the two peptides were the same. They were also independent of sex, birth weight, gestational age, umbilical cord blood pH, or glucose level. In mothers, but not in infants, plasma SS levels were higher after vaginal delivery than after cesarean section. After multiple birth, newborn plasma SS, but not plasma CCK, was significantly lower than after single birth (9.1 +/- 7.7 versus 16.9 +/- 12.7 pmol/L).
调节性肠道肽在调节胃肠道方面发挥着重要作用。我们对这些肽在早产儿中的分泌模式和功能了解甚少。因此，我们测定了65名母亲和73名早产儿（脐带血）出生后即刻的血浆生长抑素（SS）和胆囊收缩素（CCK）水平。胎龄为32（24 - 36中位数范围）周，出生体重为1900（475 - 3350）克。脐带血pH值为7.32±0.10（平均值±标准差）。血浆经Sep - Pak - C18半色谱法处理后，用放射免疫分析法测定SS和CCK。婴儿血浆中的SS和CCK水平均显著高于母亲（SS = 14.5±12.4对9.3±7.6 pmol/L；CCK = 11.6±7.4对7.0±1.9 pmol/L）。适于胎龄儿和小于胎龄儿的这两种肽的血浆水平相同。它们也与性别、出生体重、胎龄、脐带血pH值或血糖水平无关。在母亲中，经阴道分娩后的血浆SS水平高于剖宫产术后，但在婴儿中并非如此。多胎分娩后，新生儿血浆SS水平显著低于单胎分娩后（9.1±7.7对16.9±12.7 pmol/L），但血浆CCK水平无此差异。
