Lax S F, Ratschek M, Steindorfer P, Langsteger W, Harms D, Beham A
Institute of Pathology, University of Graz School of Medicine, Austria.
Pathol Res Pract. 1995 Feb;191(1):57-60; discussion 61-3. doi: 10.1016/S0344-0338(11)80924-6.
We present a 50-year-old male patient with an ossifying fibromyxoid tumour (OFMT) of the prethyroidal soft parts infiltrating the thyroid gland in coincidence with recurrent goitre, 20 years after strumectomy. The tumour, initially misdiagnosed as thyroid carcinoma and malignant schwannoma respectively, was histologically composed of typical solid cell-formations and shelly-like mature bone at the periphery. In addition, in the tissue adjacent to the tumour some foreign body granulomas with suture material and small proliferating nerves were present as a residual of the preceding strumectomy. We regard this finding as an indication of nerve sheat origin of OFMT. Follow up of 3 years after total thyroidectomy and local irradiation shows the patient free of recurrent and metastatic disease.
我们报告一例50岁男性患者,其甲状腺前软组织发生骨化性纤维黏液样肿瘤(OFMT),在甲状腺切除术后20年,该肿瘤浸润甲状腺并伴有复发性甲状腺肿。该肿瘤最初分别被误诊为甲状腺癌和恶性神经鞘瘤,组织学上由典型的实性细胞结构和周边的贝壳样成熟骨组成。此外,在肿瘤相邻组织中存在一些带有缝线材料的异物肉芽肿和小的增生神经,这是先前甲状腺切除术的残留。我们认为这一发现提示OFMT起源于神经鞘。全甲状腺切除和局部放疗后3年的随访显示患者无复发和转移疾病。