Zhou Y, Riccio D C
Department of Psychology, Kent State University, OH 44242, USA.
Physiol Behav. 1995 Jun;57(6):1107-15. doi: 10.1016/0031-9384(95)00019-f.
Three experiments were conducted to investigate the characteristics of retrograde amnesia (RA) induced by concussion in rats. In Experiment 1, rats receiving experimental concussion shortly after training in a single punishment trial exhibited severe forgetting on a retention test 48 h later. In the second experiment, rats receiving a concussion within 6 h after training showed severe RA, while those receiving concussion one day to five days after training exhibited progressively weaker amnesia. In Experiment 3, amnesic animals in one group received pretest noncontingent foot shock as a reminder treatment. This pretest cue significantly increased the cross-through latency, thus indicating a reduction in the memory deficit resulting from concussion. These results suggest that experimental concussion can be an effective method to induce retrograde memory loss in rats; that the RA caused by concussion is time-dependent; and that concussion-induced RA can be alleviated by a pretest cue indicating that the underlying mechanism of concussion-induced RA is more likely to be a retrieval deficit than a consolidation failure.
进行了三项实验以研究大鼠脑震荡诱发的逆行性遗忘（RA）的特征。在实验1中，在单次惩罚试验训练后不久接受实验性脑震荡的大鼠在48小时后的记忆保持测试中表现出严重遗忘。在第二个实验中，训练后6小时内接受脑震荡的大鼠表现出严重的逆行性遗忘，而训练后一天至五天接受脑震荡的大鼠失忆程度逐渐减弱。在实验3中，一组失忆动物接受预测试非条件足部电击作为提示处理。这个预测试提示显著增加了穿越潜伏期，从而表明脑震荡导致的记忆缺陷有所减少。这些结果表明，实验性脑震荡可能是诱导大鼠逆行性记忆丧失的有效方法；脑震荡引起的逆行性遗忘具有时间依赖性；并且脑震荡诱发的逆行性遗忘可以通过预测试提示得到缓解，这表明脑震荡诱发逆行性遗忘的潜在机制更可能是检索缺陷而非巩固失败。
