Bruder G E, Tenke C E, Stewart J W, Towey J P, Leite P, Voglmaier M, Quitkin F M
Department of Biopsychology, New York State Psychiatric Institute, NY 10032, USA.
Psychophysiology. 1995 Jul;32(4):373-81. doi: 10.1111/j.1469-8986.1995.tb01220.x.
Brain event-related potentials (ERPs) to probe tones in a dichotic complex tone test were recorded from right-handed depressed patients (n = 44) and normal subjects (n = 19) at homologous sites over left and right hemispheres (F3, F4; C3, C4; P3, P4; O1, O2). There were no differences between groups N1 or P2 amplitude, but patients had smaller P3 amplitude than did normal subjects. Depressed patients failed to show either the left ear advantage or behavior-related hemispheric asymmetry of P3 seen for normal subjects. Depressed patients also showed less difference in hemispheric asymmetry between same and different judgments. These findings indicate that the abnormal behavioral asymmetry for dichotic pitch discrimination in depressed patients reflects a reduction in hemispheric asymmetry and is related to relatively late stages of cognitive processing.
在一项双耳复合音测试中，从右利手抑郁症患者（n = 44）和正常受试者（n = 19）的左右半球同源部位（F3、F4；C3、C4；P3、P4；O1、O2）记录了对探测音的脑事件相关电位（ERP）。两组之间的N1或P2波幅没有差异，但患者的P3波幅比正常受试者小。抑郁症患者既未表现出左耳优势，也未表现出正常受试者所具有的与行为相关的P3半球不对称性。抑郁症患者在相同和不同判断之间的半球不对称性差异也较小。这些发现表明，抑郁症患者在双耳音高辨别方面的异常行为不对称反映了半球不对称性的降低，并且与认知加工的相对晚期阶段有关。
