Bruder G E, Tenke C E, Towey J P, Leite P, Fong R, Stewart J E, McGrath P J, Quitkin F M
Department of Biopsychology, New York State Psychiatric Institute, NY 10032, USA.
Psychophysiology. 1998 Jan;35(1):54-63.
Event-related potentials to binaural complex tones were recorded from 40 depressed outpatients and 22 normal control participants at 30 electrode sites. Patients did not differ from control participants in N1 or P3 amplitude but showed greater N2. N2 was greater over right than over the left hemisphere at lateral sites in patients and control participants. A P3 asymmetry was found for control participants and patients with low scores on a physical anhedonia scale, but not for patients with high anhedonia scores. Topographic (local Laplacian) maps corresponding to P3 showed greater radial current flow over right than over left central regions in control participants. Patients with high anhedonia did not show this asymmetry, whereas patients with low anhedonia showed an intermediate asymmetry. These findings support the hypothesis that anhedonic depression is associated with dysfunction of right hemisphere mechanisms mediating the processing of complex pitch information.
在30个电极位点记录了40名门诊抑郁症患者和22名正常对照参与者对双耳复合音的事件相关电位。患者与对照参与者在N1或P3波幅上没有差异，但N2波幅更大。在患者和对照参与者的外侧位点，右侧半球的N2波幅大于左侧半球。在身体快感缺失量表得分低的对照参与者和患者中发现了P3波不对称，但快感缺失得分高的患者未发现。与P3对应的地形图（局部拉普拉斯图）显示，对照参与者右侧中央区域的径向电流大于左侧。快感缺失得分高的患者未表现出这种不对称，而快感缺失得分低的患者表现出中等程度的不对称。这些发现支持了以下假设：快感缺失性抑郁症与介导复杂音调信息处理的右半球机制功能障碍有关。
