Guillem F, N'Kaoua B, Rougier A, Claverie B
Laboratoire de Neuropsychologie Expérimentale, Université de Bordeaux II, France.
Psychophysiology. 1995 Jul;32(4):382-92. doi: 10.1111/j.1469-8986.1995.tb01221.x.
To isolate the anatomical locus of the neural activity most important for generating or modulating the scalp-recorded N400 and P600 components elicited during continuous recognition memory tasks, intracranial event-related potentials (ERPs) were recorded from medial and lateral aspects of the temporal, frontal, parietal, and occipital lobes in 25 patients undergoing stereoelectroencephalography for seizure localization. Large-amplitude and polarity-inverted ERPs were recorded from various temporal, frontal, and parietal structures, whereas the memory-related ERP modulation assessed by the ERP repetition effect was present only in those brain areas that play the most important role in memory processing. These data suggest that the scalp-recorded N400 and P600 components may represent the most readily observable aspect of synchronous activity occurring across widely distributed brain structures and neural systems underlying different cognitive mechanisms, which all contribute to some aspect of information processing during recognition memory.
为了分离出在连续识别记忆任务期间产生或调节头皮记录的N400和P600成分时最重要的神经活动的解剖学部位，对25名因癫痫灶定位而接受立体脑电图检查的患者，从颞叶、额叶、顶叶和枕叶的内侧和外侧记录了颅内事件相关电位（ERP）。在颞叶、额叶和顶叶的不同结构中记录到了大幅度且极性反转的ERP，而通过ERP重复效应评估的与记忆相关的ERP调制仅出现在那些在记忆处理中起最重要作用的脑区。这些数据表明，头皮记录的N400和P600成分可能代表了跨广泛分布的脑结构和不同认知机制背后的神经系统同步活动最易于观察到的方面，这些脑结构和神经系统都对识别记忆期间信息处理的某些方面有所贡献。
