Maitre Nathalie L, Henderson Gena, Gogliotti Shirley, Pearson Jennifer, Simmons Ashley, Wang Lu, Slaughter James C, Key Alexandra P
a Department of Pediatrics , Vanderbilt University , Nashville , TN , USA.
J Clin Exp Neuropsychol. 2014;36(7):669-79. doi: 10.1080/13803395.2014.925094. Epub 2014 Jun 23.
This study examined the feasibility of using event-related potentials (ERPs) to measure changes in cortical processing following an established rehabilitative intervention (constraint-induced movement therapy, CIMT) for children with cerebral palsy (CP). Sixteen participants with a diagnosis of hemiparetic CP, with a median age of 6 years, were assessed pre and immediately post CIMT and at 6-month follow-up, using a picture-word match/mismatch discrimination task and standard neurobehavioral measures. Intervention effects were evident in improved performance on behavioral tests of sensory and motor function and the increased mean ERP amplitude of the N400 match/mismatch response on the side ipsilateral to the lesion. These effects were maintained 6 months after the intervention. No such changes were observed on the side contralateral to the lesion. This research suggests that ERPs can measure rehabilitation-induced changes in neural function in children with CP.
本研究探讨了使用事件相关电位（ERP）来测量既定康复干预（强制性运动疗法，CIMT）后脑瘫（CP）患儿皮质加工变化的可行性。16名诊断为偏瘫型CP的参与者，中位年龄为6岁，在CIMT前、CIMT后即刻以及6个月随访时进行评估，采用图片-单词匹配/不匹配辨别任务和标准神经行为测量方法。干预效果在感觉和运动功能行为测试的表现改善以及病变同侧N400匹配/不匹配反应的平均ERP波幅增加方面明显可见。这些效果在干预后6个月得以维持。在病变对侧未观察到此类变化。这项研究表明，ERP可以测量CP患儿康复引起的神经功能变化。
