生长抑素对神经降压素分泌的影响。

An effect of somatostatin on neurotensin secretion.

作者信息

Sakamoto T, Miyata M, Emoto T, Izukura M, Iwase K, Mizutani S, Matsuda H

机构信息

First Department of Surgery, Osaka University Medical School, Japan.

出版信息

Regul Pept. 1995 Apr 14;56(2-3):147-51. doi: 10.1016/0167-0115(95)00012-z.

DOI:10.1016/0167-0115(95)00012-z

PMID:7652191

Abstract

A somatostatin analog (SMS201-995) was administered subcutaneously to six totally pancreatectomized (TP) patients at five dose levels from 0 microgram/kg (control) to 2.5 micrograms/kg before ingestion of a liquid test meal, and plasma levels of neurotensin (NT) were measured. There were no significant differences in basal levels of NT between the doses of somatostatin. The NT levels were significantly elevated after ingestion of the test meal in the normal controls (n = 14). In the TP patients postprandial hypersecretion of NT was observed. The hypersecretion of NT in the patients was suppressed by SMS201-995 dose-dependently.

摘要

对6例全胰切除（TP）患者在摄入液体试验餐之前，以从0微克/千克（对照）至2.5微克/千克的五个剂量水平皮下注射一种生长抑素类似物（SMS201-995），并测定血浆神经降压素（NT）水平。生长抑素各剂量之间NT的基础水平无显著差异。正常对照者（n = 14）摄入试验餐后NT水平显著升高。在TP患者中观察到餐后NT分泌过多。患者NT的分泌过多被SMS201-995剂量依赖性地抑制。