内源性生长抑素在胃切除术后患者餐后神经降压素分泌过多中的作用。
Role of endogenous somatostatin in postprandial hypersecretion of neurotensin in patients after gastrectomy.
作者信息
Sakamoto T, Miyata M, Izukura M, Tanaka Y, Iwase K, Imabun S, Matsuda H
机构信息
First Department of Surgery, Osaka University Medical School, Japan.
出版信息
Ann Surg. 1997 Apr;225(4):377-81. doi: 10.1097/00000658-199704000-00006.
OBJECTIVE
The purpose of this report is to elucidate the mechanism of the hypersecretion of neurotensin (NT) after gastrectomy.
SUMMARY BACKGROUND DATA
NT secretion induced by fat ingestion is increased after pancreatoduodenectomy or distal gastrectomy. The hypersecretion of NT in the patients undergoing resection of the upper gastrointestinal tract is suppressed by an exogenous somatostatin (SST) analog.
METHODS
We observed simultaneously the secretion of NT and SST in the same patients before and after gastrectomy (n = 7). We also observed the secretion of these hormones induced by intraduodenal (ID) fat infusion in the normal volunteers (n = 6).
RESULTS
The response of plasma NT to fat ingestion was significantly increased after gastrectomy compared with that before gastrectomy. The response of plasma SST after gastrectomy was significantly suppressed. The response of plasma NT and SST after ID fat infusion in the normal volunteers was similar to the gastrectomized state.
CONCLUSION
Diminution of SST secretion, probably caused by the lack of SST cells in the distal part of the stomach, may play a role in augmenting NT secretion after gastrectomy.
目的
本报告旨在阐明胃切除术后神经降压素（NT）分泌过多的机制。
总结背景数据
胰十二指肠切除术或远端胃切除术后，脂肪摄入诱导的NT分泌增加。外源性生长抑素（SST）类似物可抑制上消化道切除患者的NT分泌过多。
方法
我们观察了7例患者胃切除术前和术后同一时间NT和SST的分泌情况。我们还观察了6例正常志愿者十二指肠内（ID）注入脂肪后这些激素的分泌情况。
结果
与胃切除术前相比，胃切除术后血浆NT对脂肪摄入的反应显著增加。胃切除术后血浆SST的反应显著受到抑制。正常志愿者ID注入脂肪后血浆NT和SST的反应与胃切除状态相似。
结论
胃远端SST细胞缺失可能导致SST分泌减少，这可能在胃切除术后NT分泌增加中起作用。
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