Ortega López D, Martínez Sarmiento J, Borque M, Sobrino J A, Fernández D, Calderón T, Montes E, de Pablos I, Coca E, Mallén A, Mayol J, Alvarez Fernández-Represa J
San Carlos University Hospital, Madrid, Spain.
Rev Esp Enferm Dig. 1997 Jun;89(6):425-34.
A comparative, case-control study on the pre- and postprandial release of three gastrointestinal peptides implicated in gallbladder motility has been carried out in humans in the attempt to determine their possible role in the pathogenesis of cholelithiasis. Fifty-seven adult patients (40 females and 17 males) with an ultrasound diagnosis of gallstones and 20 healthy subjects (9 females and 11 males) without cholelithiasis or other digestive pathology were studied. Plasma substance P, neurotensin and somatostatin were measured by means of RIA-I125 in basal fasting conditions and 30, 60 and 90 minutes after the oral intake of a semiliquid mixed meal. The levels of secretion of each hormone were compared in patients and healthy controls on an overall basis and in terms of sex, age and body weight. We found a basal and postprandial hypersecretion of substance P in patients with gallstones when compared with controls. Individuals with cholelithiasis showed a moderate decrease in neurotensin secretion after the oral meal. Somatostatin release was unchanged. In conclusion, patients with gallstones may present a functional disorder in the secretion of gastrointestinal hormones involved in gallbladder motility.
为了确定三种与胆囊运动有关的胃肠肽在胆石症发病机制中的可能作用，我们在人体中开展了一项关于这三种胃肠肽餐后释放情况的比较性病例对照研究。研究对象包括57例经超声诊断患有胆结石的成年患者（40例女性和17例男性）以及20例无胆石症或其他消化系统疾病的健康受试者（9例女性和11例男性）。在基础空腹状态下以及口服半流质混合餐后30、60和90分钟，采用放射免疫分析法（RIA-I125）测定血浆P物质、神经降压素和生长抑素。总体上以及按性别、年龄和体重对患者和健康对照者体内每种激素的分泌水平进行了比较。我们发现，与对照组相比，胆结石患者基础状态下及餐后P物质分泌过多。胆石症患者口服餐后神经降压素分泌出现中度下降。生长抑素释放未发生变化。总之，胆结石患者可能在参与胆囊运动的胃肠激素分泌方面存在功能紊乱。
